Laboratory of Computational and Quantitative Biology (LCQB)
UMR 7238 CNRS - Sorbonne Université
You are here
Computational prediction of dimeric transcription factor complexes
Date:
Tuesday, November 27, 2018 - 11:30
Speaker:
Jerzy Tiuryn
Address:
LCQB Kitchen,
Campus Jussieu, Bâtiment C 4e étage
4 place Jussieu, 75005 PARIS
Affiliation:
Faculty of Mathematics, Informatics and Mechanics University of Warsaw, Warsaw ( Poland)
Abstract:
The binding of transcription factors (TFs) to their specific motifs in genomic regulatory regions is commonly studied in isolation. However, in order to elucidate the mechanisms of transcriptional regulation, it is essential to determine which TFs bind DNA cooperatively as dimers and to infer the precise nature of these interactions. We will discuss an algorithm for predicting cell-type–specific TF–TF dimerization on DNA on a large scale, using DNase I hypersensitivity cell-type-specific data
Type:
Interdisciplinary Seminar
Export:
