Analytical Genomics

BIS2Analyzer is a webserver providing the online analysis of coevolving amino-acid pairs in protein alignments, especially designed for vertebrate and viral protein families, which typically display a small number of highly similar sequences. (A.Carbone team) 

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World Community Grid (WCG - IBM) posts a news on our new article appeared in Proteins exploring a fundamental principle of protein sociability.This work used data obtained in the first phase of our project "Help Cure Muscular Dystrophy Project" with WCG. This work is part of the MAPPING project (Investissement d'Avenir en Bioinformatique).

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The LCQB laboratory is in the CNRS Journal for his project MetaSUB Paris.

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World Community Grid (WCG - IBM) posts a news on our new article appeared in Proteins exploring data obtained in WCG during the "Help Cure Muscular Dystrophy Project". This work is part of the MAPPING project (Investissement d'Avenir en Bioinformatique).

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Reviens Avec Tes Prélèvements et analyse les Big Data avec nous

MetaSUB Paris : Cartographier la Diversité Microbienne du Métro Parisien. An article by Marie Pinhas (UPMC) in french to explain the involvement of the lab in the MetaSUB project. 

We published a new generation domain annotation approach, demonstrating that "multi-source" domain modelling is more appropriate than "mono-source" domain modelling for capturing remote homology. We re-annotate the Plasmodium falciparum genome.

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Alessandra Carbone organises with Ion Petre (Turku Centre for Computer Science) the special session "Computation in biological systems" at the international conference "Computability in Europe 2016", Université Paris 7, June 27th 2016 - July 1st 2016

On June 21, 2016, LCQB was the Paris Hub for the Global City Sampling Day, an international study of antimicrobial resistance spanning six continents, 32 countries and 54 cities. This event brings together more than 400 people, expected to collect about 12.000 samples of DNA, RNA and microbes from surfaces in well-traveled public meeting spaces. The data will help scientists of the MetaSub Global consortium better understand antimicrobial resistance in urban centers, and also identify new, naturally occurring drugs made by microbes, known as biosynthetic gene clusters. UPMC students in Computer Science and Molecular Biology, together with researchers collected more 80 samples at the entrance of parisian subway stations. The Paris event was organised by Hugues Richard (Analytical Genomics) and Ingrid Lafontaine (Biology of Genomes).

More information on the project: www.metasub.org

World Community Grid posts a news on Joint Evolutionary Trees 2 (JET2), a new large-scale method to predict protein-protein interfaces based on sequence and structure information.

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A novel computational approach of coevolution analysis allowed us to reconstruct the protein-protein interaction network of the Hepatitis C Virus at the residue resolution. For the first time, coevolution analysis of an entire viral genome was realized. Champeimont R, Laine E, Hu S-W, Penin F, Carbone A. Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins. Scientific Reports.