The analysis of the subtelomeres of a green alga, published in Nucleic Acids Research, is featured in this press release on the INSB website. The work, a collaboration between the LCQB ("Telomere and Genome Stability" and "Biology of Genomes" teams) and the IBPC, sheds light into the complexity and evolution of the subtelomeres, structures that are critical for genome integrity.
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Gilles FISCHER has been elected Directeur of the Sorbonne University Initiative iBio. Congratulation Gilles!
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A global study of 60 cities' microbes finds each has a signature microbial fingerprint. The project provides a great way to communicate about the invisible world of commensal microorganisms. Members at the LCQB, L3 and M1 Sorbonne’s students involved in our Bioinformatics courses and colleagues from other Sorbonne departments contributed to the collect of the samples for the Paris area. The article just appeared in Cell.
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Marco Cosentino-Lagomarsino and Gilles Fischer collaborated with Gianni Liti’s team to generatate end-to-end genome assemblies for 12 yeast genomes based on long-read sequencing. These population-level high-quality genomes with comprehensive annotation enable the first explicit definition of chromosomal boundaries between core and subtelomeric regions as well as a precise quantification of their relative evolutionary rates of genome dynamics.
To the article
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On June 21, 2016, LCQB was the Paris Hub for the Global City Sampling Day, an international study of antimicrobial resistance spanning six continents, 32 countries and 54 cities. This event brings together more than 400 people, expected to collect about 12.000 samples of DNA, RNA and microbes from surfaces in well-traveled public meeting spaces. The data will help scientists of the MetaSub Global consortium better understand antimicrobial resistance in urban centers, and also identify new, naturally occurring drugs made by microbes, known as biosynthetic gene clusters. UPMC students in Computer Science and Molecular Biology, together with researchers collected more 80 samples at the entrance of parisian subway stations. The Paris event was organised by Hugues Richard (Analytical Genomics) and Ingrid Lafontaine (Biology of Genomes).
More information on the project: www.metasub.org
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We achieved the complete reconstruction of genome history in a model yeast genus, providing a granular view of genome evolution linking gene content, chromosome rearrangements and protein divergence into a single evolutionary framework.
N Vakirlis, Sarilar V, G Drillon, A Fleiss, N Agier, J-P Meyniel, L Blanpain, A Carbone, H Devillers, K Dubois, A Gillet-Markowska, S Graziani, Nguyen H-V, M Poirel, C Reisser, J Schott, J Schacherer, I Lafontaine, B Llorente, C Neuvéglise and Fischer G. Reconstruction of ancestral chromosome architecture and gene repertoire reveals principles of genome evolution in a model yeast genus. Genome Research (2016).
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